National Science Council Project Grant
Product formulation development, stability assessment and preclinical pharmacokinetic evaluation
Providing Everything You Need
After active screening, active ingredient prediction and purification, and genotoxicity analysis (safety assessment), natural resources can eventually be developed into oral or topical products.
Product formulation development
Oral products (tablets, drops)
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The Parallel Artificial Membrane Permeability Assay (PAMPA) in vitro model is used to rapidly evaluate the intestinal absorption of active ingredients. In addition, it also provides the evaluation of product disintegration and solubility as well as the analysis of the interaction between the excipient and the active ingredient.
Topical preparations (emulsions)
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Franz diffusion cells, PAMPA and other models are used to quickly evaluate the penetration of active ingredients into the stratum corneum barrier
Stability Assessment
By storing the product at specific temperature (25 30, 40°C) and humidity (60, 65, 70% RH) conditions and taking samples at regular intervals for analysis, the residual amount of the index/active ingredient can be determined, thereby evaluating its storage stability.
Preclinical pharmacokinetics
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Oral bioavailability can be calculated by oral feeding, drug administration through femoral vein cannulation, and blood sampling at multiple time points through cervical vein cannulation to quantify the blood concentration of the active ingredient and to understand the degree of absorption.
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Microdialysis sampling technology can evaluate the dynamic concentration distribution of drugs (such as blood-muscle distribution, blood-brain tissue distribution).